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CAH-Mass

2nd tier LC-MS/MS Kit for Congenital Adrenal Hyperplasia.Congenital adrenal hyperplasia (CAH) refers to a group of autosomal recessive disorders that impair cortisol biosynthesis. CAH represents a continuous phenotypic spectrum with over 95% of all cases caused by 21-hydroxylase deficiency. CAH owing to 21-hydroxylase deficiency is the most common cause of genital ambiguity in the newborn and is present in about 1 in 15,000 live births worldwide

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Overview
Features

Overview

Quantitative determination of17-hydroxyprogesterone, Androstenedione, Cortisol, 11-deoxycortisol and 21-deoxycortisol in Dried Blood Spot Samples

Features

Liquid Chromatography - Tandem mass spectrometry (LC-MS/MS) techniques allows for the simultaneous specific determination of 17-OHP and other steroids related with CAH such as androstenedione, cortisol, 11-deoxycortisol, and 21-deoxycortisol. Application of this technology to the determination of steroids in newborn blood spots significantly enhances the correct identification of patients with CAH and reduces the number of false-positive screening results when implemented as a second-tier analysis performed prior to reporting of initial newborn screen results.

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